A Novel Single-Cell FISH-Flow Assay Identifies Effector Memory CD4<sup>+</sup> T cells as a Major Niche for HIV-1 Transcription in HIV-Infected Patients

A Novel Single-Cell FISH-Flow Assay Identifies Effector Memory CD4<sup>+</sup> T cells as a Major Niche for HIV-1 Transcription in HIV-Infected Patients

ABSTRACT Cells that actively transcribe HIV-1 have been defined as the “active viral reservoir” in HIV-infected individuals. However, important technical limitations have precluded the characterization of this specific viral reservoir during both treated and untreated HIV-1 infections. Here, we used...

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Bibliographic Details
Main Authors: Judith Grau-Expósito, Carla Serra-Peinado, Lucia Miguel, Jordi Navarro, Adrià Curran, Joaquin Burgos, Imma Ocaña, Esteban Ribera, Ariadna Torrella, Bibiana Planas, Rosa Badía, Josep Castellví, Vicenç Falcó, Manuel Crespo, Maria J. Buzon
Format: Article
Language:English
Published: American Society for Microbiology 2017-09-01
Series:mBio
Subjects:
viral persistence
viral reactivation
viral reservoirs
human immunodeficiency virus
Online Access:https://journals.asm.org/doi/10.1128/mBio.00876-17

Internet

https://journals.asm.org/doi/10.1128/mBio.00876-17

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