Agonists Specific for κ-Opioid Receptor Induces Apoptosis of HCC Cells Through Enhanced Endoplasmic Reticulum Stress

Agonists Specific for κ-Opioid Receptor Induces Apoptosis of HCC Cells Through Enhanced Endoplasmic Reticulum Stress

Cancer pain is an important factor affecting life quality of patients especially in the advanced stage and relieving pain is one of fundamental strategies for cancer treatment. Opioids such as morphine are the most widely used in clinics. However, they have been reported to be associated with the oc...

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Bibliographic Details
Main Authors: Mengyuan Tan, Hanyu Wang, Cheng Gao, Zhen Jiang, Ying Yin, Ruyi Xing, Ling Hu, Jiegou Xu, Min Zhang, Yanhu Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
opioid receptors
opioid agonists
hepatocellular carcinoma
apoptosis
PERK pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.844214/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.844214/full

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