An order-to-disorder structural switch activates the FoxM1 transcription factor

An order-to-disorder structural switch activates the FoxM1 transcription factor

Intrinsically disordered transcription factor transactivation domains (TADs) function through structural plasticity, adopting ordered conformations when bound to transcriptional co-regulators. Many transcription factors contain a negative regulatory domain (NRD) that suppresses recruitment of transc...

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Bibliographic Details
Main Authors: Aimee H Marceau, Caileen M Brison, Santrupti Nerli, Heather E Arsenault, Andrew C McShan, Eefei Chen, Hsiau-Wei Lee, Jennifer A Benanti, Nikolaos G Sgourakis, Seth M Rubin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
transcription factors
intrinsically disordered proteins
Cdk
Plk1
nuclear magnetic resonance
Online Access:https://elifesciences.org/articles/46131

Internet

https://elifesciences.org/articles/46131

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