An order-to-disorder structural switch activates the FoxM1 transcription factor
Intrinsically disordered transcription factor transactivation domains (TADs) function through structural plasticity, adopting ordered conformations when bound to transcriptional co-regulators. Many transcription factors contain a negative regulatory domain (NRD) that suppresses recruitment of transc...
Main Authors: | Aimee H Marceau, Caileen M Brison, Santrupti Nerli, Heather E Arsenault, Andrew C McShan, Eefei Chen, Hsiau-Wei Lee, Jennifer A Benanti, Nikolaos G Sgourakis, Seth M Rubin |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-05-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/46131 |
Similar Items
-
Centrosomes and associated proteins in pathogenesis and treatment of breast cancer
by: Harjot Athwal, et al.
Published: (2024-03-01) -
CDC2 Is an Important Driver of Vascular Smooth Muscle Cell Proliferation via FOXM1 and PLK1 in Pulmonary Arterial Hypertension
by: Ruma Pal-Ghosh, et al.
Published: (2021-06-01) -
PLK1 and FoxM1 expressions positively correlate in papillary thyroid carcinoma and their combined inhibition results in synergistic anti‐tumor effects
by: Pratheesh Kumar Poyil, et al.
Published: (2024-03-01) -
Invasive FoxM1 phosphorylated by PLK1 induces the polarization of tumor-associated macrophages to promote immune escape and metastasis, amplified by IFITM1
by: Rong Xu, et al.
Published: (2023-11-01) -
Targeting CBX3 with a Dual BET/PLK1 Inhibitor Enhances the Antitumor Efficacy of CDK4/6 Inhibitors in Prostate Cancer
by: Huaiyuan Liang, et al.
Published: (2023-12-01)