Activated CLL cells regulate IL-17F–producing Th17 cells in miR155-dependent and outcome-specific manners

Activated CLL cells regulate IL-17F–producing Th17 cells in miR155-dependent and outcome-specific manners

Chronic lymphocytic leukemia (CLL) results from expansion of a CD5+ B cell clone that requires interactions with other cell types, including T cells. Moreover, patients with CLL have elevated levels of circulating IL-17A+ and IL-17F+ CD4+ T (Th17) cells, with higher numbers of IL-17A+ Th17 cells cor...

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Bibliographic Details
Main Authors: Byeongho Jung, Gerardo Ferrer, Pui Yan Chiu, Rukhsana Aslam, Anita Ng, Florencia Palacios, Michael Wysota, Martina Cardillo, Jonathan E. Kolitz, Steven L. Allen, Jacqueline C. Barrientos, Kanti R. Rai, Nicholas Chiorazzi, Barbara Sherry
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-06-01
Series:JCI Insight
Subjects:
Hematology
Immunology
Online Access:https://doi.org/10.1172/jci.insight.158243

Internet

https://doi.org/10.1172/jci.insight.158243

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