Loss of Thymine DNA Glycosylase Causes Dysregulation of Bile Acid Homeostasis and Hepatocellular Carcinoma

Loss of Thymine DNA Glycosylase Causes Dysregulation of Bile Acid Homeostasis and Hepatocellular Carcinoma

Summary: Thymine DNA glycosylase (TDG) is a nuclear receptor coactivator that plays an essential role in the maintenance of epigenetic stability in cells. Here, we demonstrate that the conditional deletion of TDG in adult mice results in a male-predominant onset of hepatocellular carcinoma (HCC). TD...

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Bibliographic Details
Main Authors: Haider M. Hassan, Majdina Isovic, Bart Kolendowski, Natasha Bauer-Maison, Oladapo Onabote, Matthew Cecchini, Aaron Haig, Saman Maleki Vareki, T. Michael Underhill, Joseph Torchia
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720303533

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http://www.sciencedirect.com/science/article/pii/S2211124720303533

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