Reprogramming of iron metabolism confers ferroptosis resistance in ECM-detached cells

Reprogramming of iron metabolism confers ferroptosis resistance in ECM-detached cells

Summary: Cancer cells often acquire resistance to cell death programs induced by loss of integrin-mediated attachment to extracellular matrix (ECM). Given that adaptation to ECM-detached conditions can facilitate tumor progression and metastasis, there is significant interest in effective eliminatio...

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Bibliographic Details
Main Authors: Jianping He, Abigail M. Abikoye, Brett P. McLaughlin, Ryan S. Middleton, Ryan Sheldon, Russell G. Jones, Zachary T. Schafer
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:iScience
Subjects:
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223009045

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http://www.sciencedirect.com/science/article/pii/S2589004223009045

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