Rosmarinic Acid, as an NHE1 Activator, Decreases Skin Surface pH and Improves the Skin Barrier Function

Rosmarinic Acid, as an NHE1 Activator, Decreases Skin Surface pH and Improves the Skin Barrier Function

Stratum corneum (SC) pH regulates skin barrier functions and elevated SC pH is an important factor in various inflammatory skin diseases. Acidic topical formulas have emerged as treatments for impaired skin barriers. Sodium proton exchanger 1 (NHE1) is an important factor in SC acidification. We inv...

Full description

Bibliographic Details
Main Authors:	Seung-Won Jung, Gi Hyun Park, Eunjung Kim, Kang Min Yoo, Hea Won Kim, Jin Soo Lee, Min Youl Chang, Kyong-Oh Shin, Kyungho Park, Eung Ho Choi
Format:	Article
Language:	English
Published:	MDPI AG 2022-03-01
Series:	International Journal of Molecular Sciences
Subjects:	skin barrier skin pH sodium proton exchanger 1 <i>Melissa officinalis</i> leaf extract rosmarinic acid
Online Access:	https://www.mdpi.com/1422-0067/23/7/3910

Similar Items

Chitosan enhances rosmarinic acid production in shoot cultures of Melissa officinalis L. through the induction of methyl jasmonate
by: Ghazaleh Fooladi vanda, et al.
Published: (2019-10-01)

Effect of graphene / metal nanocomposites on the key genes involved in rosmarinic acid biosynthesis pathway and its accumulation in Melissa officinalis
by: Roya Karimi Soraki, et al.
Published: (2021-06-01)

Nitric Oxide Increased the Rosmarinic Acid and Essential Oil Production in In vitro-cultured Melissa officinalis
by: S Esmaeilzadeh bahabadi, et al.
Published: (2018-03-01)

Modulation of chicken gut contractility by Melissa officinalis—ex vivo study
by: Martyna A. Posłuszny, et al.
Published: (2023-11-01)

In Vitro Cultured <i>Melissa officinalis</i> Cells as Effective Ingredient to Protect Skin against Oxidative Stress, Blue Light, and Infrared Irradiations Damages
by: Giovanna Pressi, et al.
Published: (2021-03-01)

Release of rosmarinic acid from semisolid formulations and its penetration through human skin ex vivo
by: Stelmakienė Ada, et al.
Published: (2015-06-01)

The Valorisation of <i>Melissa officinalis</i> Distillation By-Products for the Production of Polyphenol-Rich Formulations
by: Eirini Stini, et al.
Published: (2024-01-01)

Effect of salicylic acid on antioxidant properties of In vitro proliferated shoots of Melissa officinalisL.
by: Maryam ٍEbrahimi, et al.
Published: (2019-03-01)

Dietary Intake of Rosmarinic Acid Increases Serum Inhibitory Activity in Amyloid A Aggregation and Suppresses Deposition in the Organs of Mice
by: Xuguang Lin, et al.
Published: (2020-08-01)

Biodiversity within Melissa officinalis: Variability of Bioactive Compounds in a Cultivated Collection
by: Remigius Chizzola, et al.
Published: (2018-01-01)

Safety and Efficacy of Dextran-Rosmarinic Acid Conjugates as Innovative Polymeric Antioxidants in Skin Whitening: What Is the Evidence?
by: Ortensia I. Parisi, et al.
Published: (2017-08-01)

The Stimulating Effect of Rosmarinic Acid and Extracts from Rosemary and Lemon Balm on Collagen Type I Biosynthesis in Osteogenesis Imperfecta Type I Skin Fibroblasts
by: Joanna Sutkowska, et al.
Published: (2021-06-01)

The Effects of Medicinal Plants of Melissa officinalis and Salvia officinalis on Primary Dysmenorrhea
by: Ramezan Kalvandi, et al.
Published: (2014-09-01)

Comparison of Analgesic Effect of Rosmarinic Acid With Piroxicam in Mice
by: Mohsen Moradi, et al.
Published: (2022-03-01)

Formulation of a Sedative Film Coated Tablet from Extracts of Melissa officinalis and Valeriana officinalis
by: SE Sajjadi, et al.
Published: (2003-03-01)

The effect of hydroalcoholic extract of Melissa Officinalis in prevention of convulsions induced by Nicotine in mice
by: A Arzi, et al.
Published: (2002-04-01)

Subcritical Water Extraction of Rosmarinic Acid from Lemon Balm (<i>Melissa officinalis</i> L.) and Its Effect on Plant Cell Wall Constituents
by: Ana Atanasova, et al.
Published: (2023-04-01)

Antifungal Activity and Type of Interaction of <i>Melissa officinalis</i> Essential Oil with Antimycotics against Biofilms of Multidrug-Resistant <i>Candida</i> Isolates from Vulvovaginal Mucosa
by: Marina Ranđelović, et al.
Published: (2023-11-01)

Electrospun PLA-Based Biomaterials Loaded with <i>Melissa officinalis</i> Extract with Strong Antioxidant Activity
by: Nikoleta Stoyanova, et al.
Published: (2023-02-01)

SUSCEPTIBILITY OF LEMON BALM (Melissa officinalis L.) VARIETIES TO SEPTORIA LEAF SPOT (Septoria melissae Desm.) IN HUNGARY
by: Gergő Kovács, et al.
Published: (2019-02-01)

Oral Intake of <i>Hydrangea serrata</i> (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study
by: Da-Bin Myung, et al.
Published: (2020-05-01)

Rosmarinic Acid Multifunctional Sunscreen: Comet Assay and In Vivo Establishment of Cutaneous Attributes
by: Thalita Marcílio Cândido, et al.
Published: (2022-12-01)

<i>Rosmarinus officinalis</i> and Skin: Antioxidant Activity and Possible Therapeutical Role in Cutaneous Diseases
by: Federica Li Pomi, et al.
Published: (2023-03-01)

Development of enriced butter
by: N. S. Bezverkhaya, et al.
Published: (2021-12-01)

Development of Essential Oil-Loaded Polymeric Nanocapsules as Skin Delivery Systems: Biophysical Parameters and Dermatokinetics Ex Vivo Evaluation
by: Perla Giovanna Silva-Flores, et al.
Published: (2023-10-01)

Comparative effects of balm hydro alcoholic extract and diazepam on reducing anxiety of in mice
by: M Modaresi, et al.
Published: (2016-01-01)

Negative Chronotropic and Antidysrhythmic Effects of Hydroalcoholic Extract of Lemon Balm (Melissa Officinalis L.) on CaCl2-Induced Arrhythmias in Rats
by: Zahra Akhondali, et al.
Published: (2015-02-01)

Evaluation of Melissa officinalis (Lemon Balm) effects on heart electrical system
by: Siyavash Joukar, et al.
Published: (2015-01-01)

"Repellent Effect of Extracts and Essential Oils of Citrus limon (Rutaceae) and Melissa officinalis (Labiatae) Against Main Malaria Vector, Anopheles stephensi (Diptera: Culicidae)"
by: "MA Oshaghi, et al.
Published: (2003-10-01)

The therapeutic potential of Melissa officinalis L. hydroalcoholic extract and rosmarinic acid in a rat asthmatic model: A study on anti-inflammatory and antioxidant effects
by: Vahideh Abbasnia, et al.
Published: (2024-03-01)

Effects of Carbohydrates on Rosmarinic Acid Production and In Vitro Antimicrobial Activities in Hairy Root Cultures of <i>Agastache rugosa</i>
by: Hyeon Ji Yeo, et al.
Published: (2023-02-01)

Chemical Composition, In Vitro and In Silico Antioxidant Potential of <i>Melissa officinalis</i> subsp. <i>officinalis</i> Essential Oil
by: Matilda Rădulescu, et al.
Published: (2021-07-01)

Pattern of skin diseases in Imphal
by: Devi Th. Bijayanti, et al.
Published: (2006-01-01)

Effect of <i>Cirsium japonicum</i> Flower Extract on Skin Aging Induced by Glycation
by: Sohyun Yoon, et al.
Published: (2022-03-01)

Development of Ultradeformable Liposomes with Fatty Acids for Enhanced Dermal Rosmarinic Acid Delivery
by: Thirapit Subongkot, et al.
Published: (2021-03-01)

The Use of Matriderm and Autologous Skin Graft in the Treatment of Full Thickness Skin Defects
by: Jang Hwan Min, et al.
Published: (2014-07-01)

<i>Melissa officinalis</i> L. Aqueous Extract Exerts Antioxidant and Antiangiogenic Effects and Improves Physiological Skin Parameters
by: Simona Sipos, et al.
Published: (2021-04-01)

A Narrative Review of Alternative Symptomatic Treatments for Herpes Simplex Virus
by: Jane Y. Chang, et al.
Published: (2023-06-01)

The Influence of Drying Treatments on the Essential Oil Content and Composition of Melissa officinalis L. Compared with the Fresh Sample
by: Seyed Fazel Mirahmadi, et al.
Published: (2017-02-01)

Assessment of cutaneous parameters and sympathetic skin response as a non-invasive complementary diagnostic tool in psoriasis: An exploratory study
by: L Sundareswaran, et al.
Published: (2023-01-01)