Suppression of interferon α and γ response by Huwe1-mediated Miz1 degradation promotes SARS-CoV-2 replication

Suppression of interferon α and γ response by Huwe1-mediated Miz1 degradation promotes SARS-CoV-2 replication

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been demonstrated to limit the host interferon response; however, the underlying mechanism remains unclear. Here, we found that SARS-CoV-2 infection upregulated the E3 ubiquitin ligase Huwe1, which in turn facilitated the degradation o...

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Bibliographic Details
Main Authors: Vinothini Arunagiri, Laura Cooper, Huali Dong, Jake Class, Indrani Biswas, Sujan Vahora, Riddhi Deshpande, Khushi H. Gopani, Guochang Hu, Justin M. Richner, Lijun Rong, Jing Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-07-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
interferon alpha and gamma responses
Miz1
HUWE1
transcriptional regulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1388517/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1388517/full

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