An essential Trypanosoma brucei protein kinase: a functional analysis of regulation and the identification of inhibitors

An essential Trypanosoma brucei protein kinase: a functional analysis of regulation and the identification of inhibitors

IntroductionThe protein serine/threonine kinase AEK1 is essential in the pathogenic stage of Trypanosoma brucei, the causative agent of African trypanosomiasis. AEK1 is a member of the AGC protein kinase family, although it is not closely related to a specific human AGC kinase. Our previous chemical...

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Bibliographic Details
Main Authors: Marilyn Parsons, Ben Parsons, Marissa Dean, Amy E. DeRocher, Zeba Islam, Dustin J. Maly, Bryan C. Jensen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Parasitology
Subjects:
protein kinase
Trypanosoma brucei
AGC kinase
African trypanosomiasis
hesperadin
inhibitor screen
Online Access:https://www.frontiersin.org/articles/10.3389/fpara.2023.1272378/full

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https://www.frontiersin.org/articles/10.3389/fpara.2023.1272378/full

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