Disruption of GPR35 Signaling in Bone Marrow-Derived Cells Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice

Disruption of GPR35 Signaling in Bone Marrow-Derived Cells Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice

G-protein-coupled receptor-35 (GPR35) has been identified as a receptor for the tryptophan metabolite kynurenic acid (KynA) and suggested to modulate macrophage polarization in metabolic tissues. Whether GPR35 can influence vascular inflammation and atherosclerosis has however never been tested. Let...

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Bibliographic Details
Main Authors: Roland Baumgartner, Felipe B. Casagrande, Randi B. Mikkelsen, Martin Berg, Konstantinos A. Polyzos, Maria J. Forteza, Aastha Arora, Thue W. Schwartz, Siv A. Hjorth, Daniel F. J. Ketelhuth
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Metabolites
Subjects:
atherosclerosis
GPR35
inflammation
immunometabolism
kynurenine
tryptophan
Online Access:https://www.mdpi.com/2218-1989/11/7/411

Internet

https://www.mdpi.com/2218-1989/11/7/411

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