Interplay of Prenatal and Postnatal Risk Factors in the Behavioral and Histological Features of a “Two-Hit” Non-Genetic Mouse Model of Schizophrenia

Interplay of Prenatal and Postnatal Risk Factors in the Behavioral and Histological Features of a “Two-Hit” Non-Genetic Mouse Model of Schizophrenia

Schizophrenia is a multifactorial developmental neuropsychiatric disorder. This study examined the interplay of maternal infection and postweaning social isolation, which are prenatal and postnatal risk factors, respectively. Pregnant mice received poly I:C or saline injection on gestation day 9 and...

Full description

Bibliographic Details
Main Authors: Yi-Chun Chang, Wai-Yu Li, Lukas Jyuhn-Hsiarn Lee, Li-Jen Lee
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
risk factors
schizophrenia
stress-coping
ventral tegmental area (VTA)
mPFC
dendritic structure
Online Access:https://www.mdpi.com/1422-0067/21/22/8518

Internet

https://www.mdpi.com/1422-0067/21/22/8518

Similar Items