Proteogenomic identification of an immunogenic antigen derived from human endogenous retrovirus in renal cell carcinoma
CD8+ T cells can recognize tumor antigens displayed by HLA class I molecules and eliminate tumor cells. Despite their low tumor mutation burden, immune checkpoint blockade (ICB) is often beneficial in patients with renal cell carcinoma (RCC). Here, using a proteogenomic approach, we directly and com...
| Autori principali: | , , , , , , , , |
|---|---|
| Natura: | Articolo |
| Lingua: | English |
| Pubblicazione: |
American Society for Clinical investigation
2023-08-01
|
| Serie: | JCI Insight |
| Soggetti: | |
| Accesso online: | https://doi.org/10.1172/jci.insight.167712 |