Endoplasmic reticulum-associated SARS-CoV-2 ORF3a elicits heightened cytopathic effects despite robust ER-associated degradation

Endoplasmic reticulum-associated SARS-CoV-2 ORF3a elicits heightened cytopathic effects despite robust ER-associated degradation

ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF3a protein plays a vital role in viral pathogenesis and coronavirus disease 2019 (COVID-19). Like the spike protein, ORF3a mutates frequently, and certain variants are associated with the severity of COVID-19. Given the clinical...

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Bibliographic Details
Main Authors: Jiantao Zhang, Ruth Cruz-Cosme, Chenyu Zhang, Dongxiao Liu, Qiyi Tang, Richard Y. Zhao
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:mBio
Subjects:
SARS-CoV-2
ORF3a mutants
ER and lysosomes
apoptosis
NF-kB
TNFα and IL-6
Online Access:https://journals.asm.org/doi/10.1128/mbio.03030-23

Internet

https://journals.asm.org/doi/10.1128/mbio.03030-23

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