Genistein ameliorated experimentally induced gastric ulcer in rats via inhibiting gastric tissues fibrosis by modulating Wnt/β-catenin/TGF-β/PKB pathway

Genistein ameliorated experimentally induced gastric ulcer in rats via inhibiting gastric tissues fibrosis by modulating Wnt/β-catenin/TGF-β/PKB pathway

ABSTRACTObjectives Gastric ulcer (GU) is a prevalent chronic digestive disease affecting about 10% of the world's population leading to gastrointestinal perforation and bleeding. Genistein is a legume flavonoid with antioxidants, anti-inflammatory and antibacterial activities. Therefore, we aim...

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Bibliographic Details
Main Authors: Hanan M. Hassan, Nouf M. Alatawi, Alaa Bagalagel, Reem Diri, Ahmad Noor, Deina Almasri, Hussain T. Bakhsh, Hussam I. Kutbi, Noha Ashy, Mohammed M. H. Al-Gayyar
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Redox Report
Subjects:
β-catenin
gastric ulcer
protein kinase B (PKB)
SMAD4
transforming growth factor (TGF)-β
Wnt
Online Access:https://www.tandfonline.com/doi/10.1080/13510002.2023.2218679

Internet

https://www.tandfonline.com/doi/10.1080/13510002.2023.2218679

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