The Lrat<sup>−/−</sup> Rat: CRISPR/Cas9 Construction and Phenotyping of a New Animal Model for Retinitis Pigmentosa

The Lrat<sup>−/−</sup> Rat: CRISPR/Cas9 Construction and Phenotyping of a New Animal Model for Retinitis Pigmentosa

Purpose: We developed and phenotyped a pigmented knockout rat model for lecithin retinol acyltransferase (LRAT) using CRISPR/Cas9. The introduced mutation (c.12delA) is based on a patient group harboring a homologous homozygous frameshift mutation in the <i>LRAT</i> gene (c.12delC), caus...

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Bibliographic Details
Main Authors: Céline Koster, Koen T. van den Hurk, Colby F. Lewallen, Mays Talib, Jacoline B. ten Brink, Camiel J. F. Boon, Arthur A. Bergen
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
lecithin retinol acyltransferase (LRAT)
pigmented rat model
retinal pigment epithelium (RPE)
retinal degeneration
retinal dystrophy
retinitis pigmentosa
Online Access:https://www.mdpi.com/1422-0067/22/13/7234

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https://www.mdpi.com/1422-0067/22/13/7234

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