Beyond IC50-A computational dynamic model of drug resistance in enzyme inhibition treatment.

Resistance to therapy is a major clinical obstacle to treatment of cancer and communicable diseases. Drug selection in treatment of patients where the disease is showing resistance to therapy is often guided by IC50 or fold-IC50 values. In this work, through a model of the treatment of chronic myelo...

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Bibliographic Details
Main Authors: J Roadnight Sheehan, Astrid S de Wijn, Thales Souza Freire, Ran Friedman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-11-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1012570