Did Amino Acid Side Chain Reactivity Dictate the Composition and Timing of Aminoacyl-tRNA Synthetase Evolution?

The twenty amino acids in the standard genetic code were fixed prior to the last universal common ancestor (LUCA). Factors that guided this selection included establishment of pathways for their metabolic synthesis and the concomitant fixation of substrate specificities in the emerging aminoacyl-tRN...

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Bibliographic Details
Main Authors: Tamara L. Hendrickson, Whitney N. Wood, Udumbara M. Rathnayake
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Genes
Subjects:
Online Access:https://www.mdpi.com/2073-4425/12/3/409