Preventing erosion of X-chromosome inactivation in human embryonic stem cells

Preventing erosion of X-chromosome inactivation in human embryonic stem cells

Cloutier et al. discover that human embryonic stem cells (hESCs) cultured with media containing inhibitors of GSK3 proteins undergo erosion of X-chromosome inactivation, which equalizes X-linked gene expression between females and males. The findings inform the faithful culture of hESCs.

Bibliographic Details
Main Authors: Marissa Cloutier, Surinder Kumar, Emily Buttigieg, Laura Keller, Brandon Lee, Aaron Williams, Sandra Mojica-Perez, Indri Erliandri, Andre Monteiro Da Rocha, Kenneth Cadigan, Gary D. Smith, Sundeep Kalantry
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30259-x

Internet

https://doi.org/10.1038/s41467-022-30259-x

Similar Items