Enhancing a Sphaerobacter thermophilus ω-transaminase for kinetic resolution of β- and γ-amino acids

Enhancing a Sphaerobacter thermophilus ω-transaminase for kinetic resolution of β- and γ-amino acids

Abstract Sphaerobacter thermophilus synthesizes an ω-transaminase (ω-TA) that allows the production of enantiomerically pure β-amino acids. To obtain ω-TA variants with a higher activity and more favorable properties for industrial use, we modified critical amino acid residues either in the catalyti...

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Bibliographic Details
Main Authors: Uwe Wegner, Falko Matthes, Nicolaus von Wirén, Ina Lemke, Rüdiger Bode, H.-Matthias Vorbrodt, Marion Rauter, Gotthard Kunze
Format: Article
Language:English
Published: SpringerOpen 2023-10-01
Series:AMB Express
Subjects:
ω-Transaminase
Sphaerobacter thermophilus
Optimization
ß- and γ-amino acids
Kinetic resolution
Online Access:https://doi.org/10.1186/s13568-023-01623-x

Internet

https://doi.org/10.1186/s13568-023-01623-x

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