In Vitro and In Vivo Efficacy of a Novel Glucose–Methotrexate Conjugate in Targeted Cancer Treatment

Methotrexate (MTX) is a commonly used antimetabolite, which inhibits folate and DNA synthesis to be effective in the treatment of various malignancies. However, MTX therapy is hindered by the lack of target tumor selectivity. We have designed, synthesized and evaluated a novel glucose–methotrexate c...

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Bibliographic Details
Main Authors: Marta Woźniak, Gabriela Pastuch-Gawołek, Sebastian Makuch, Jerzy Wiśniewski, Tibor Krenács, Peter Hamar, Andrzej Gamian, Wiesław Szeja, Danuta Szkudlarek, Monika Krawczyk, Siddarth Agrawal
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
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Online Access:https://www.mdpi.com/1422-0067/22/4/1748