Deep mutational scanning identifies sites in influenza nucleoprotein that affect viral inhibition by MxA.
The innate-immune restriction factor MxA inhibits influenza replication by targeting the viral nucleoprotein (NP). Human influenza virus is more resistant than avian influenza virus to inhibition by human MxA, and prior work has compared human and avian viral strains to identify amino-acid differenc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-03-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC5383324?pdf=render |