Peri-operative pharmacokinetics of cefazolin prophylaxis during valve replacement surgery.

Peri-operative pharmacokinetics of cefazolin prophylaxis during valve replacement surgery.

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<h4>Objective</h4>There is little prospective data to guide effective dosing for antibiotic prophylaxis during surgery requiring cardiopulmonary bypass (CPB). We aim to describe the effects of CPB on the population pharmacokinetics (PK) of total and unbound concentrations of cefazolin an...

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Bibliographic Details
Main Authors: Ahmad Alli, Fathima Paruk, Claire Roger, Jeffrey Lipman, Daren Calleemalay, Steven C Wallis, Juan Scribante, Guy A Richards, Jason A Roberts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0291425

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https://doi.org/10.1371/journal.pone.0291425

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