Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols

Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols

Dumesnil et al. report that cholesterol esters (CE), which only melt above body temperature, form supercooled liquid crystalline lipid droplets (LD). Triacylglycerols (TG) solubilize CE to help CE LD nucleation. Through clustering TGs in the ER membrane, seipin controls CE LD nucleation sites.

Bibliographic Details
Main Authors: Calvin Dumesnil, Lauri Vanharanta, Xavier Prasanna, Mohyeddine Omrane, Maxime Carpentier, Apoorva Bhapkar, Giray Enkavi, Veijo T. Salo, Ilpo Vattulainen, Elina Ikonen, Abdou Rachid Thiam
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36375-6

Internet

https://doi.org/10.1038/s41467-023-36375-6

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