Parthenolide promotes expansion of Nestin+ progenitor cells via Shh modulation and contributes to post-injury cerebellar replenishment

Parthenolide promotes expansion of Nestin+ progenitor cells via Shh modulation and contributes to post-injury cerebellar replenishment

Background: Regeneration of injuries occurring in the central nervous system is extremely difficult. Studies have shown that the developing cerebellum can be repopulated by a group of Nestin-expressing progenitors (NEPs) after irradiation injury, suggesting that modulating the mobilization of NEPs i...

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Bibliographic Details
Main Authors: Dong Jinling, Feng Liyuan, Fu Wenying, Huang Yuting, Tang Xiangyu, Huang Xiuning, Tang Yu, Ming Qianliang, Guo Linming, Gao Ning, Li Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
parthenolide
cerebellum
NEPs
Shh
irradiation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1051103/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1051103/full

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