Antifungal Potential of Synthetic Peptides against <i>Cryptococcus neoformans</i>: Mechanism of Action Studies Reveal Synthetic Peptides Induce Membrane–Pore Formation, DNA Degradation, and Apoptosis

Antifungal Potential of Synthetic Peptides against <i>Cryptococcus neoformans</i>: Mechanism of Action Studies Reveal Synthetic Peptides Induce Membrane–Pore Formation, DNA Degradation, and Apoptosis

<i>Cryptococcus neoformans</i> is a human-pathogenic yeast responsible for pneumonia and meningitis, mainly in patients immunocompromised. Infections caused by <i>C. neoformans</i> are a global health concern. Synthetic antimicrobial peptides (SAMPs) have emerged as alternati...

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Bibliographic Details
Main Authors: Tawanny K. B. Aguiar, Nilton A. S. Neto, Cleverson D. T. Freitas, Ayrles F. B. Silva, Leandro P. Bezerra, Ellen A. Malveira, Levi A. C. Branco, Felipe P. Mesquita, Gustavo H. Goldman, Luciana M. R. Alencar, Jose T. A. Oliveira, Ralph Santos-Oliveira, Pedro F. N. Souza
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceutics
Subjects:
synthetic antifungal peptides
<i>Cryptococcus neoformans</i>
cryptococcal meningitis
inhibition
apoptosis induction
Online Access:https://www.mdpi.com/1999-4923/14/8/1678

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https://www.mdpi.com/1999-4923/14/8/1678

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