High-sensitivity analysis of clonal hematopoiesis reveals increased clonal complexity of potential-driver mutations in severe COVID-19 patients.

High-sensitivity analysis of clonal hematopoiesis reveals increased clonal complexity of potential-driver mutations in severe COVID-19 patients.

Whether Clonal Hematopoiesis (CH) represents a risk factor for severity of the COVID-19 disease remains a controversial issue. We report the first high- sensitivity analysis of CH in COVID-19 patients (threshold of detection at 0.5% vs 1 or 2% in previous studies). We analyzed 24 patients admitted t...

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Bibliographic Details
Main Authors: Chiara Ronchini, Chiara Caprioli, Gianleo Tunzi, Francesco Furio D'Amico, Emanuela Colombo, Marco Giani, Giuseppe Foti, Donatella Conconi, Marialuisa Lavitrano, Rita Passerini, Luca Pase, Silvio Capizzi, Fabrizio Mastrilli, Myriam Alcalay, Roberto Orecchia, Gioacchino Natoli, Pier Giuseppe Pelicci
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0282546&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0282546&type=printable

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