Association between APOE-ε4 allele and cognitive function is mediated by Alzheimer’s disease pathology: a population-based autopsy study in an admixed sample

Association between APOE-ε4 allele and cognitive function is mediated by Alzheimer’s disease pathology: a population-based autopsy study in an admixed sample

Abstract Background Apolipoprotein E ε4 allele (APOE-ε4) is the main genetic risk factor for late-onset Alzheimer’s disease (AD) and may impact cognitive function also via other neuropathological lesions. However, there is limited evidence available from diverse populations, as APOE associations wit...

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Bibliographic Details
Main Authors: Regina Silva Paradela, Alberto Fernando Oliveira Justo, Vítor Ribeiro Paes, Renata E. P. Leite, Carlos A. Pasqualucci, Lea T. Grinberg, Michel Satya Naslavsky, Mayana Zatz, Ricardo Nitrini, Wilson Jacob-Filho, Claudia Kimie Suemoto
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Acta Neuropathologica Communications
Subjects:
Apolipoprotein E
Cognition
Dementia
Neuritic plaques
Neurofibrillary tangles
Mediation analysis
Online Access:https://doi.org/10.1186/s40478-023-01681-z

Internet

https://doi.org/10.1186/s40478-023-01681-z

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