Distinct Responsiveness of Tumor-Associated Macrophages to Immunotherapy of Tumors with Different Mechanisms of Major Histocompatibility Complex Class I Downregulation

Distinct Responsiveness of Tumor-Associated Macrophages to Immunotherapy of Tumors with Different Mechanisms of Major Histocompatibility Complex Class I Downregulation

Tumor-associated macrophages (TAMs) plentifully infiltrate the tumor microenvironment (TME), but their role in anti-tumor immunity is controversial. Depending on the acquired polarization, they can either support tumor growth or participate in the elimination of neoplastic cells. In this study, we a...

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Bibliographic Details
Main Authors: Adrianna Piatakova, Ingrid Polakova, Jana Smahelova, Shweta Dilip Johari, Jaroslav Nunvar, Michal Smahel
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
repolarization
macrophages
tumor
immunotherapy
major histocompatibility complex
colony-stimulating factor-1
Online Access:https://www.mdpi.com/2072-6694/13/12/3057

Internet

https://www.mdpi.com/2072-6694/13/12/3057

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