Rational Engineering of (<i>S</i>)-Norcoclaurine Synthase for Efficient Benzylisoquinoline Alkaloids Biosynthesis

Rational Engineering of (<i>S</i>)-Norcoclaurine Synthase for Efficient Benzylisoquinoline Alkaloids Biosynthesis

(<i>S</i>)-Norcoclaurine is synthesized in vivo through a metabolic pathway that ends with (<i>S</i>)-norcoclaurine synthase (NCS). The former constitutes the scaffold for the biosynthesis of all benzylisoquinoline alkaloids (BIAs), including many drugs such as the opiates mo...

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Bibliographic Details
Main Authors: João P. M. De Sousa, Nuno C. S. A. Oliveira, Pedro A. Fernandes
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Molecules
Subjects:
enzyme catalysis
protein engineering
alkaloid biosynthesis
benzylisoquinoline alkaloids
(<i>S</i>)-norcoclaurine
Online Access:https://www.mdpi.com/1420-3049/28/11/4265

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https://www.mdpi.com/1420-3049/28/11/4265

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