Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia

Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia

Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) share several common pathophysiological features. Rare variants of triggering receptor expressed on myeloid cells 2 (TREM2) increase the risk of developing AD, suggesting the involvement of TREM2 and innate immunity in AD development....

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Bibliographic Details
Main Authors: Min Wu, Maolin Liao, Rongfeng Huang, Chunxiu Chen, Tian Tian, Hongying Wang, Jiayu Li, Jibin Li, Yuxiang Sun, Chaodong Wu, Qifu Li, Xiaoqiu Xiao
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-03-01
Series:Genes and Diseases
Subjects:
Diabetes
Microglial polarization
Neurodegeneration
Neuroinflammation
Obesity
TREM2
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304220300702

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http://www.sciencedirect.com/science/article/pii/S2352304220300702

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