Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55–IL6ST Gene Region in Immature Dendritic Cells

Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55–IL6ST Gene Region in Immature Dendritic Cells

Intronic single-nucleotide polymorphisms (SNPs) in the ANKRD55 gene are associated with the risk for multiple sclerosis (MS) and rheumatoid arthritis by genome-wide association studies (GWAS). The risk alleles have been linked to higher expression levels of ANKRD55 and the neighboring IL6ST (gp130)...

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Main Authors: Jorge Mena, Iraide Alloza, Raquel Tulloch Navarro, Ane Aldekoa, Javier Díez García, Ane Villanueva Etxebarria, Cecilia Lindskog, Alfredo Antigüedad, Sabas Boyero, María del Mar Mendibe-Bilbao, Amaya Álvarez de Arcaya, José Luis Sánchez Menoyo, Luciana Midaglia, Noelia Villarrubia, Sunny Malhotra, Xavier Montalban, Luisa María Villar, Manuel Comabella, Koen Vandenbroeck
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
ANKRD55
IL6ST
sgp130
multiple sclerosis
autoimmune
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.816930/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.816930/full

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