Auditory brainstem response deficits in learning disorders and developmental language disorder: a systematic review and meta-analysis
Abstract Although learning disorders (LD) and developmental language disorder (DLD) can be linked to overlapping psychological and behavioral deficits, such as phonological, morphological, orthographic, semantic, and syntactic deficits, as well as academic (e.g., reading) difficulties, they are curr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-20438-7 |
| _version_ | 1811186992727195648 |
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| author | Lisa K. Chinn Marina A. Zhukova Ryan J. Kroeger Leandro M. Ledesma Joslyn E. Cavitt Elena L. Grigorenko |
| author_facet | Lisa K. Chinn Marina A. Zhukova Ryan J. Kroeger Leandro M. Ledesma Joslyn E. Cavitt Elena L. Grigorenko |
| author_sort | Lisa K. Chinn |
| collection | DOAJ |
| description | Abstract Although learning disorders (LD) and developmental language disorder (DLD) can be linked to overlapping psychological and behavioral deficits, such as phonological, morphological, orthographic, semantic, and syntactic deficits, as well as academic (e.g., reading) difficulties, they are currently separate diagnoses in the DSM-5 with explicit phenotypic differences. At a neural level, it is yet to be determined to what extent they have overlapping or distinct signatures. The identification of such neural markers/endophenotypes could be important for the development of physiological diagnostic tools, as well as an understanding of disorders across different dimensions, as recommended by the Research Domain Criteria Initiative (RDoC). The current systematic review and meta-analysis examined whether the two disorders can be differentiated based on the auditory brainstem response (ABR). Even though both diagnoses require hearing problems to be ruled out, a number of articles have demonstrated associations of these disorders with the auditory brainstem response. We demonstrated that both LD and DLD are associated with longer latencies in ABR Waves III, V, and A, as well as reduced amplitude in Waves V and A. However, multilevel subgroup analyses revealed that LD and DLD do not significantly differ for any of these ABR waves. Results suggest that less efficient early auditory processing is a shared mechanism underlying both LD and DLD. |
| first_indexed | 2024-04-11T13:54:34Z |
| format | Article |
| id | doaj.art-1cbf7b31c5624078b96f62eb4c642fd9 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T13:54:34Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1cbf7b31c5624078b96f62eb4c642fd92022-12-22T04:20:22ZengNature PortfolioScientific Reports2045-23222022-11-0112111410.1038/s41598-022-20438-7Auditory brainstem response deficits in learning disorders and developmental language disorder: a systematic review and meta-analysisLisa K. Chinn0Marina A. Zhukova1Ryan J. Kroeger2Leandro M. Ledesma3Joslyn E. Cavitt4Elena L. Grigorenko5Department of Psychology, University of HoustonDepartment of Psychology, University of HoustonDepartment of Psychology, University of HoustonDepartment of Psychology, University of HoustonDepartment of Psychology, University of HoustonDepartment of Psychology, University of HoustonAbstract Although learning disorders (LD) and developmental language disorder (DLD) can be linked to overlapping psychological and behavioral deficits, such as phonological, morphological, orthographic, semantic, and syntactic deficits, as well as academic (e.g., reading) difficulties, they are currently separate diagnoses in the DSM-5 with explicit phenotypic differences. At a neural level, it is yet to be determined to what extent they have overlapping or distinct signatures. The identification of such neural markers/endophenotypes could be important for the development of physiological diagnostic tools, as well as an understanding of disorders across different dimensions, as recommended by the Research Domain Criteria Initiative (RDoC). The current systematic review and meta-analysis examined whether the two disorders can be differentiated based on the auditory brainstem response (ABR). Even though both diagnoses require hearing problems to be ruled out, a number of articles have demonstrated associations of these disorders with the auditory brainstem response. We demonstrated that both LD and DLD are associated with longer latencies in ABR Waves III, V, and A, as well as reduced amplitude in Waves V and A. However, multilevel subgroup analyses revealed that LD and DLD do not significantly differ for any of these ABR waves. Results suggest that less efficient early auditory processing is a shared mechanism underlying both LD and DLD.https://doi.org/10.1038/s41598-022-20438-7 |
| spellingShingle | Lisa K. Chinn Marina A. Zhukova Ryan J. Kroeger Leandro M. Ledesma Joslyn E. Cavitt Elena L. Grigorenko Auditory brainstem response deficits in learning disorders and developmental language disorder: a systematic review and meta-analysis Scientific Reports |
| title | Auditory brainstem response deficits in learning disorders and developmental language disorder: a systematic review and meta-analysis |
| title_full | Auditory brainstem response deficits in learning disorders and developmental language disorder: a systematic review and meta-analysis |
| title_fullStr | Auditory brainstem response deficits in learning disorders and developmental language disorder: a systematic review and meta-analysis |
| title_full_unstemmed | Auditory brainstem response deficits in learning disorders and developmental language disorder: a systematic review and meta-analysis |
| title_short | Auditory brainstem response deficits in learning disorders and developmental language disorder: a systematic review and meta-analysis |
| title_sort | auditory brainstem response deficits in learning disorders and developmental language disorder a systematic review and meta analysis |
| url | https://doi.org/10.1038/s41598-022-20438-7 |
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