Long-Term Antitumor CD8<sup>+</sup> T Cell Immunity Induced by Endogenously Engineered Extracellular Vesicles

Long-Term Antitumor CD8<sup>+</sup> T Cell Immunity Induced by Endogenously Engineered Extracellular Vesicles

We developed an innovative method to induce antigen-specific CD8<sup>+</sup> T cytotoxic lymphocyte (CTL) immunity based on in vivo engineering of extracellular vesicles (EVs). This approach employs a DNA vector expressing a mutated HIV-1 Nef protein (Nef<sup>mut</sup>) depri...

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Bibliographic Details
Main Authors: Flavia Ferrantelli, Francesco Manfredi, Chiara Chiozzini, Patrizia Leone, Andrea Giovannelli, Eleonora Olivetta, Maurizio Federico
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
extracellular vesicles
antitumor vaccines
HPV16
CD8<sup>+</sup> T cell immunity
Online Access:https://www.mdpi.com/2072-6694/13/9/2263

Internet

https://www.mdpi.com/2072-6694/13/9/2263

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