Population Analysis of <named-content content-type="genus-species">Staphylococcus aureus</named-content> Reveals a Cryptic, Highly Prevalent Superantigen SElW That Contributes to the Pathogenesis of Bacteremia

Population Analysis of <named-content content-type="genus-species">Staphylococcus aureus</named-content> Reveals a Cryptic, Highly Prevalent Superantigen SElW That Contributes to the Pathogenesis of Bacteremia

ABSTRACT Staphylococcal superantigens (SAgs) are a family of secreted toxins that stimulate T cell activation and are associated with an array of diseases in humans and livestock. Most SAgs produced by Staphylococcus aureus are encoded by mobile genetic elements, such as pathogenicity islands, bacte...

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Bibliographic Details
Main Authors: Manouk Vrieling, Stephen W. Tuffs, Gonzalo Yebra, Marleen Y. van Smoorenburg, Joana Alves, Amy C. Pickering, Joo Youn Park, Nogi Park, David E. Heinrichs, Lindert Benedictus, Timothy Connelley, Keun Seok Seo, John K. McCormick, J. Ross Fitzgerald
Format: Article
Language:English
Published: American Society for Microbiology 2020-10-01
Series:mBio
Subjects:
Staphylococcus aureus
T cells
evolution
pathogenesis
superantigens
Online Access:https://journals.asm.org/doi/10.1128/mBio.02082-20

Internet

https://journals.asm.org/doi/10.1128/mBio.02082-20

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