Kidney-Specific CAP1/Prss8-Deficient Mice Maintain ENaC-Mediated Sodium Balance through an Aldosterone Independent Pathway

Kidney-Specific CAP1/Prss8-Deficient Mice Maintain ENaC-Mediated Sodium Balance through an Aldosterone Independent Pathway

The serine protease prostasin (CAP1/Prss8, channel-activating protease-1) is a confirmed in vitro and in vivo activator of the epithelial sodium channel ENaC. To test whether proteolytic activity or CAP1/Prss8 abundance itself are required for ENaC activation in the kidney, we studied animals either...

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Bibliographic Details
Main Authors: Elodie Ehret, Yannick Jäger, Chloé Sergi, Anne-Marie Mérillat, Thibaud Peyrollaz, Deepika Anand, Qing Wang, Fréderique Ino, Marc Maillard, Stephan Kellenberger, Ivan Gautschi, Roman Szabo, Thomas H. Bugge, Lotte K. Vogel, Edith Hummler, Simona Frateschi
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
CAP1/Prss8
ENaC activation
Online Access:https://www.mdpi.com/1422-0067/23/12/6745

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https://www.mdpi.com/1422-0067/23/12/6745

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