Senataxin and RNase H2 act redundantly to suppress genome instability during class switch recombination

Senataxin and RNase H2 act redundantly to suppress genome instability during class switch recombination

Class switch recombination generates distinct antibody isotypes critical to a robust adaptive immune system, and defects are associated with autoimmune disorders and lymphomagenesis. Transcription is required during class switch recombination to recruit the cytidine deaminase AID—an essential step f...

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Bibliographic Details
Main Authors: Hongchang Zhao, Stella R Hartono, Kirtney Mae Flores de Vera, Zheyuan Yu, Krishni Satchi, Tracy Zhao, Roger Sciammas, Lionel Sanz, Frédéric Chédin, Jacqueline Barlow
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-12-01
Series:eLife
Subjects:
class switch recombination
R loops
DNA repair
Online Access:https://elifesciences.org/articles/78917

Internet

https://elifesciences.org/articles/78917

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