A Novel Class of FKBP12 Ligands Rescues Premature Aging Phenotypes Associated with Myotonic Dystrophy Type 1

A Novel Class of FKBP12 Ligands Rescues Premature Aging Phenotypes Associated with Myotonic Dystrophy Type 1

<b>Background:</b> Myotonic dystrophy type 1 (DM1) is an autosomal dominant disorder clinically characterized by progressive muscular weakness and multisystem degeneration, which correlates with the size of CTG expansion and MBLN decrease. These changes induce a calcium and redox homeost...

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Bibliographic Details
Main Authors: Mikel García-Puga, Gorka Gerenu, Ariadna Bargiela, Jorge Espinosa-Espinosa, Laura Mosqueira-Martín, Maialen Sagartzazu-Aizpurua, Jesús M. Aizpurua, Ainara Vallejo-Illarramendi, Rubén Artero, Adolfo López de Munain, Ander Matheu
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Cells
Subjects:
myotonic dystrophy
FKBP12/RyR interaction
oxidative stress
extended longevity
multisystem recovery
Online Access:https://www.mdpi.com/2073-4409/13/23/1939

Internet

https://www.mdpi.com/2073-4409/13/23/1939

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