Interleukin-34 restores blood-brain barrier integrity by upregulating tight junction proteins in endothelial cells.
Interleukin-34 (IL-34) is a newly discovered cytokine as an additional ligand for colony stimulating factor-1 receptor (CSF1R), and its functions are expected to overlap with colony stimulating factor-1/macrophage-colony stimulating factor. We have previously shown that the IL-34 is primarily produc...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4275171?pdf=render |
| _version_ | 1819125081905823744 |
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| author | Shijie Jin Yoshifumi Sonobe Jun Kawanokuchi Hiroshi Horiuchi Yi Cheng Yue Wang Tetsuya Mizuno Hideyuki Takeuchi Akio Suzumura |
| author_facet | Shijie Jin Yoshifumi Sonobe Jun Kawanokuchi Hiroshi Horiuchi Yi Cheng Yue Wang Tetsuya Mizuno Hideyuki Takeuchi Akio Suzumura |
| author_sort | Shijie Jin |
| collection | DOAJ |
| description | Interleukin-34 (IL-34) is a newly discovered cytokine as an additional ligand for colony stimulating factor-1 receptor (CSF1R), and its functions are expected to overlap with colony stimulating factor-1/macrophage-colony stimulating factor. We have previously shown that the IL-34 is primarily produced by neurons in the central nervous system (CNS) and induces proliferation and neuroprotective properties of microglia which express CSF1R. However, the functions of IL-34 in the CNS are still elucidative. Here we show that CNS capillary endothelial cells also express CSF1R. IL-34 protected blood-brain barrier integrity by restored expression levels of tight junction proteins, which were downregulated by pro-inflammatory cytokines. The novel function of IL-34 on the blood-brain barrier may give us a clue for new therapeutic strategies in neuroinflammatory and neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease. |
| first_indexed | 2024-12-22T07:34:28Z |
| format | Article |
| id | doaj.art-1cc7e1e80d9741ed82211e2464474066 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T07:34:28Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1cc7e1e80d9741ed82211e24644740662022-12-21T18:33:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11598110.1371/journal.pone.0115981Interleukin-34 restores blood-brain barrier integrity by upregulating tight junction proteins in endothelial cells.Shijie JinYoshifumi SonobeJun KawanokuchiHiroshi HoriuchiYi ChengYue WangTetsuya MizunoHideyuki TakeuchiAkio SuzumuraInterleukin-34 (IL-34) is a newly discovered cytokine as an additional ligand for colony stimulating factor-1 receptor (CSF1R), and its functions are expected to overlap with colony stimulating factor-1/macrophage-colony stimulating factor. We have previously shown that the IL-34 is primarily produced by neurons in the central nervous system (CNS) and induces proliferation and neuroprotective properties of microglia which express CSF1R. However, the functions of IL-34 in the CNS are still elucidative. Here we show that CNS capillary endothelial cells also express CSF1R. IL-34 protected blood-brain barrier integrity by restored expression levels of tight junction proteins, which were downregulated by pro-inflammatory cytokines. The novel function of IL-34 on the blood-brain barrier may give us a clue for new therapeutic strategies in neuroinflammatory and neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease.http://europepmc.org/articles/PMC4275171?pdf=render |
| spellingShingle | Shijie Jin Yoshifumi Sonobe Jun Kawanokuchi Hiroshi Horiuchi Yi Cheng Yue Wang Tetsuya Mizuno Hideyuki Takeuchi Akio Suzumura Interleukin-34 restores blood-brain barrier integrity by upregulating tight junction proteins in endothelial cells. PLoS ONE |
| title | Interleukin-34 restores blood-brain barrier integrity by upregulating tight junction proteins in endothelial cells. |
| title_full | Interleukin-34 restores blood-brain barrier integrity by upregulating tight junction proteins in endothelial cells. |
| title_fullStr | Interleukin-34 restores blood-brain barrier integrity by upregulating tight junction proteins in endothelial cells. |
| title_full_unstemmed | Interleukin-34 restores blood-brain barrier integrity by upregulating tight junction proteins in endothelial cells. |
| title_short | Interleukin-34 restores blood-brain barrier integrity by upregulating tight junction proteins in endothelial cells. |
| title_sort | interleukin 34 restores blood brain barrier integrity by upregulating tight junction proteins in endothelial cells |
| url | http://europepmc.org/articles/PMC4275171?pdf=render |
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