The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma

The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma

Abstract The drivers of recurrence and resistance in ovarian high grade serous carcinoma remain unclear. We investigate the acquisition of resistance by collecting tumour biopsies from a cohort of 276 women with relapsed ovarian high grade serous carcinoma in the BriTROC-1 study. Panel sequencing sh...

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Bibliographic Details
Main Authors: Philip Smith, Thomas Bradley, Lena Morrill Gavarró, Teodora Goranova, Darren P. Ennis, Hasan B. Mirza, Dilrini De Silva, Anna M. Piskorz, Carolin M. Sauer, Sarwah Al-Khalidi, Ionut-Gabriel Funingana, Marika A. V. Reinius, Gaia Giannone, Liz-Anne Lewsley, Jamie Stobo, John McQueen, Gareth Bryson, Matthew Eldridge, The BriTROC Investigators, Geoff Macintyre, Florian Markowetz, James D. Brenton, Iain A. McNeish
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39867-7

Internet

https://doi.org/10.1038/s41467-023-39867-7

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