Gastrodin Alleviates Oxidative Stress-Induced Apoptosis and Cellular Dysfunction in Human Umbilical Vein Endothelial Cells via the Nuclear Factor-Erythroid 2-Related Factor 2/Heme Oxygenase-1 Pathway and Accelerates Wound Healing In Vivo

Gastrodin Alleviates Oxidative Stress-Induced Apoptosis and Cellular Dysfunction in Human Umbilical Vein Endothelial Cells via the Nuclear Factor-Erythroid 2-Related Factor 2/Heme Oxygenase-1 Pathway and Accelerates Wound Healing In Vivo

Aims: To explore the effect and mechanism of gastrodin (GAS) on human umbilical vein endothelial cells (HUVECs) apoptosis induced by oxidative stress and its function in wound healing.Main methods: HUVECs were incubated with tert-butyl hydroperoxide (TBHP) to induce endothelial cell dysfunction and...

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Bibliographic Details
Main Authors: Jialiang Lin, Yifeng Shi, Jiansen Miao, Yuhao Wu, Hao Lin, Jianwei Wu, Weimin Zeng, Fangzhou Qi, Chen Liu, Xiangyang Wang, Haiming Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
gastrodin
wound healing
angiogenesis
apoptosis
Nrf2/HO-1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01273/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01273/full

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