PYK2 promotes HER2-positive breast cancer invasion

PYK2 promotes HER2-positive breast cancer invasion

Abstract Background Metformin, a biguanide, is one of the most commonly prescribed treatments for type 2 diabetes and has recently been recommended as a potential drug candidate for advanced cancer therapy. Although Metformin has antiproliferative and proapoptotic effects on breast cancer, the heter...

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Bibliographic Details
Main Authors: Shaymaa IK. Al-Juboori, Jayakumar Vadakekolathu, Sarra Idri, Sarah Wagner, Dimitrios Zafeiris, Joshua RD. Pearson, Rukaia Almshayakhchi, Michele Caraglia, Vincenzo Desiderio, Amanda K. Miles, David J. Boocock, Graham R. Ball, Tarik Regad
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pure HER2 breast Cancer
Metformin
PYK2/PTK2B
Chemoresistance
Breast cancer stem cells
Online Access:http://link.springer.com/article/10.1186/s13046-019-1221-0

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http://link.springer.com/article/10.1186/s13046-019-1221-0

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