PKCε activator protects hippocampal microvascular disruption and memory defect in 3×Tg-Alzheimer’s disease mice with cerebral microinfarcts

PKCε activator protects hippocampal microvascular disruption and memory defect in 3×Tg-Alzheimer’s disease mice with cerebral microinfarcts

BackgroundCurrent evidence suggests that microvessel disease is involved in Alzheimer’s disease (AD). Cerebrovascular disease correlates with cardiovascular disease and is complicated in ≈40% of AD patients. The protein kinase C (PKC) ε activator DCPLA can stimulate human antigen (Hu) R that prevent...

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Bibliographic Details
Main Authors: Huaixing Wang, Zongxiu Zhang, Jarin Hongpaisan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Aging Neuroscience
Subjects:
cerebrovascular disease
microvessel
hypoxia
oxidative stress
VEGF
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1272361/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1272361/full

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