Physiologically-Based Pharmacokinetic Modelling to Predict the Pharmacokinetics and Pharmacodynamics of Linezolid in Adults and Children with Tuberculous Meningitis

Physiologically-Based Pharmacokinetic Modelling to Predict the Pharmacokinetics and Pharmacodynamics of Linezolid in Adults and Children with Tuberculous Meningitis

Linezolid is used off-label for treatment of central nervous system infections. However, its pharmacokinetics and target attainment in cranial cerebrospinal fluid (CSF) in tuberculous meningitis patients is unknown. This study aimed to predict linezolid cranial CSF concentrations and assess attainme...

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Bibliographic Details
Main Authors: Carlijn H. C. Litjens, Laurens F. M. Verscheijden, Elin M. Svensson, Petra H. H. van den Broek, Hedwig van Hove, Jan B. Koenderink, Frans G. M. Russel, Rob E. Aarnoutse, Lindsey H. M. te Brake
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Antibiotics
Subjects:
PBPK
linezolid
tuberculous meningitis
Online Access:https://www.mdpi.com/2079-6382/12/4/702

Internet

https://www.mdpi.com/2079-6382/12/4/702

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