Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis

Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis

Objective: Cancer cells convert more glucose into lactate than healthy cells, what contributes to their growth advantage. Pyruvate kinase (PK) is a key rate limiting enzyme in this process, what makes it a promising potential therapeutic target. However, currently it is still unclear what consequenc...

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Bibliographic Details
Main Authors: Anna Nieborak, Saulius Lukauskas, Jordi Capellades, Patricia Heyn, Gabriela Silva Santos, Karsten Motzler, Anja Zeigerer, Romina Bester, Ulrike Protzer, Florian Schelter, Mirko Wagner, Thomas Carell, Alexander Hruscha, Bettina Schmid, Oscar Yanes, Robert Schneider
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Molecular Metabolism
Subjects:
Pyruvate kinase
Cancer
ROS
Glycolysis
Thioredoxin-interacting protein
Arrestins
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823000820

Internet

http://www.sciencedirect.com/science/article/pii/S2212877823000820

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