Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice

Abstract Background Acute liver failure resulting from drug-induced liver injury can lead to the development of neurological complications called hepatic encephalopathy (HE). Hepatic transforming growth factor beta 1 (TGFβ1) is upregulated due to liver failure in mice and inhibiting circulating TGFβ...

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Bibliographic Details
Main Authors: Matthew McMillin, Stephanie Grant, Gabriel Frampton, Anca D. Petrescu, Elaina Williams, Brandi Jefferson, Alison Thomas, Ankita Brahmaroutu, Sharon DeMorrow
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Neuroinflammation
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12974-019-1455-y