Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice
Abstract Background Acute liver failure resulting from drug-induced liver injury can lead to the development of neurological complications called hepatic encephalopathy (HE). Hepatic transforming growth factor beta 1 (TGFβ1) is upregulated due to liver failure in mice and inhibiting circulating TGFβ...
Main Authors: | Matthew McMillin, Stephanie Grant, Gabriel Frampton, Anca D. Petrescu, Elaina Williams, Brandi Jefferson, Alison Thomas, Ankita Brahmaroutu, Sharon DeMorrow |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-04-01
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Series: | Journal of Neuroinflammation |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12974-019-1455-y |
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