Precisely Activating cGAS‐STING Pathway with a Novel Peptide‐Based Nanoagonist to Potentiate Immune Checkpoint Blockade Cancer Immunotherapy

Precisely Activating cGAS‐STING Pathway with a Novel Peptide‐Based Nanoagonist to Potentiate Immune Checkpoint Blockade Cancer Immunotherapy

Abstract As an essential intracellular immune activation pathway, the cGAS‐STING pathway has attracted broad attention in cancer treatment. However, low bioavailability, nonspecificity, and adverse effects of small molecule STING agonists severely limit their therapeutic efficacy and in vivo applica...

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Bibliographic Details
Main Authors: Yumeng Xing, Ao Peng, Jianhui Yang, Zhifei Cheng, Yi Yue, Feilong Liu, Fenghe Li, Yang Liu, Qi Liu
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Advanced Science
Subjects:
antimicrobial peptides
cancer immunotherapy
cGAS‐STING activation
multi‐stimuli activatable
PD‐1/PD‐L1 blockade
Online Access:https://doi.org/10.1002/advs.202309583

Internet

https://doi.org/10.1002/advs.202309583

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