Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload

Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload

Myopalladin (MYPN) is a striated muscle-specific immunoglobulin domain-containing protein located in the sarcomeric Z-line and I-band. MYPN gene mutations are causative for dilated (DCM), hypertrophic, and restrictive cardiomyopathy. In a yeast two-hybrid screening, MYPN was found to bind to titin i...

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Bibliographic Details
Main Authors: Maria Carmela Filomena, Daniel L Yamamoto, Pierluigi Carullo, Roman Medvedev, Andrea Ghisleni, Nicoletta Piroddi, Beatrice Scellini, Roberta Crispino, Francesca D'Autilia, Jianlin Zhang, Arianna Felicetta, Simona Nemska, Simone Serio, Chiara Tesi, Daniele Catalucci, Wolfgang A Linke, Roman Polishchuk, Corrado Poggesi, Mathias Gautel, Marie-Louise Bang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
sarcomere
Z-line
dilated cardiomyopathy
knockout mice
transaortic constriction
Online Access:https://elifesciences.org/articles/58313

Internet

https://elifesciences.org/articles/58313

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