Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection.
The blood-clotting protein fibrin(ogen) plays a critical role in host defense against invading pathogens, particularly against peritoneal infection by the Gram-positive microbe Staphylococcus aureus. Here, we tested the hypothesis that direct binding between fibrin(ogen) and S. aureus is a component...
Main Authors: | Oscar Negrón, Woosuk S Hur, Joni Prasad, David S Paul, Sarah E Rowe, Jay L Degen, Sara R Abrahams, Silvio Antoniak, Brian P Conlon, Wolfgang Bergmeier, Magnus Hӧӧk, Matthew J Flick |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2022-01-01
|
Series: | PLoS Pathogens |
Online Access: | https://doi.org/10.1371/journal.ppat.1010227 |
Similar Items
-
Fibrin(ogen) and neurodegeneration in the progressive multiple sclerosis cortex
by: Yates, R, et al.
Published: (2017) -
Fibrin(ogen) as a Therapeutic Target: Opportunities and Challenges
by: Thembaninkosi G. Gaule, et al.
Published: (2021-06-01) -
Thrombin–Fibrin(ogen) Interactions, Host Defense and Risk of Thrombosis
by: Anne-Marije Hulshof, et al.
Published: (2021-03-01) -
Cellular mechanisms of fibrin (ogen): insight from neurodegenerative diseases
by: Tingting Wen, et al.
Published: (2023-07-01) -
Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?
by: Alexandre Slater, et al.
Published: (2019-04-01)